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Which compound is least basic structure?

NI3 is least basic because Iodine has vacant d orbital hence it can accept lone pair of electrons from Nitrogen and help in back bonding. Also, basicity decreases down the group and in this manner as well NI3 is less basic than any other given compounds.

Where are amides used?

The unsubstituted aliphatic carboxylic acid amides have wide use as intermediates, stabilizers, release agents for plastics, films, surfactants and soldering fluxes. The substituted amides such as dimethylformamide and dimethylacetamide have powerful solvent properties.

Why is Lda a strong base?

Strong organic bases such as LDA (Lithium DiisopropylAmide) can be used to drive the ketone-enolate equilibrium completely to the enolate side. LDA is a strong base that is useful for this purpose. The steric bulk of its isopropyl groups makes LDA non- nucleophilic. Even so, it’s a strong base.

What is LDA THF?

Because of its solubility in THF, LDA is a widely used base for enolate anion formation. Although the reaction of carbonyl compounds with sodium hydride is heterogeneous and slow, sodium enolates are formed with the loss of hydrogen, and no other organic compounds are produced.

How do you quench and butyllithium?

Use the 2-propanol carefully. Drop the n-Buli slowly into cooled 2-propanol. Ice cooling is sufficient. Isopropanol and 2-propanol are one and the same.

How do you make LDA?

LDA is commonly formed by treating a cooled (0 to −78 °C) mixture of tetrahydrofuran and diisopropylamine with n-butyllithium. When dissociated, the diisopropylamide anion can become protonated to form diisopropylamine.

Is BuLi a strong base?

Furthermore, in addition to being a strong nucleophile, n-BuLi binds to aprotic Lewis bases, such as ethers and tertiary amines, which partially disaggregate the clusters by binding to the lithium centers. Its use as a strong base is referred to as metalation.